Journal of Molecular Evolution

, Volume 46, Issue 5, pp 612-614

Presence of a Fibronectin Type III Domain in a Plant Protein

  • Irina  TsyguelnaiaAffiliated withCenter for Molecular Genetics, University of California, San Diego, La Jolla, CA 92039-0634, USA
  • , Russell F.  DoolittleAffiliated withCenter for Molecular Genetics, University of California, San Diego, La Jolla, CA 92039-0634, USA

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Abstract.

A hidden Markov model (HMM) approach was used to identify potential candidates in sequence databases for fibronectin type III domains in plants, a kingdom heretofore bereft of these structures. Fortuitously, one of the proteins uncovered had already had a crystal structure published, allowing direct structural confirmation of the existence of this domain in plants.

Key words: Fibronectin type III domains — Plant proteins — HMM search