Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 10, pp 1658–1665

A specialized mitochondrial molecular chaperone system:¶A role in formation of Fe/S centers

  • E. A. Craig
  • J. Marszalek

DOI: 10.1007/PL00012493

Cite this article as:
Craig, E. & Marszalek, J. CMLS, Cell. Mol. Life Sci. (2002) 59: 1658. doi:10.1007/PL00012493

Abstract.

Mitochondria contain a specialized system of molecular chaperones that plays a critical role in the biogenesis of Fe/S centers. This Hsp70:J-protein system shows many similarities to the system found in bacteria, but the precise role of neither chaperone system has been defined. However, evidence to date suggests an interaction with the scaffold protein on which a transient Fe/S center is assembled, and thus implies a role in either assembly of the center or its transfer to recipient proteins.

Key words. Mitochondria; Hsp70; Fe/S center; iron; Jac1; Ssq1; molecular chaperone. 

Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • E. A. Craig
    • 1
  • J. Marszalek
    • 2
  1. 1.Department of Biomolecular Chemistry, 1300 University Avenue, University of Wisconsin, Madison, Wisconsin 53706 (USA), Fax +1 608 262 5253; e-mail: ecraig@facstaff.wisc.eduUS
  2. 2.Department of Molecular and Cellular Biology, Faculty of Biotechnology, University of Gdansk, 80-822 Gdansk, Kladki 24 (Poland)PL