Human Genetics

, Volume 100, Issue 2, pp 151–154

Assignment of human genes for β2 and β4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23

  • S. Taviaux
  • M. E. Williams
  • M. M. Harpold
  • J. Nargeot
  • P. Lory
Original investigation

DOI: 10.1007/PL00008704

Cite this article as:
Taviaux, S., Williams, M., Harpold, M. et al. Hum Genet (1997) 100: 151. doi:10.1007/PL00008704

Abstract

We have used human β2 and β4 cDNA probes to map the genes encoding two isoforms of the regulatory β subunit of voltage-activated Ca2+ channels, viz. CACNB2 (β2) and CACNB4 (β4), to human chromosomes 10p12 and 2q22-q23, respectively, by fluorescence in situ hybridization. The gene encoding the β2 protein, first described as a Lambert-Eaton myasthenic syndrome (LEMS) antigen in humans, is found close to a region that undergoes chromosome rearrangements in small cell lung cancer, which occurs in association with LEMS. CACNB2 (β2) and CACNB4 (β4) genes are members of the ion-channel gene superfamily and it should now be possible to examine their loci by linkage analysis of ion-channel-related disorders. To date, no such disease-related gene has been assigned to 10p12 and 2q22-q23.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. Taviaux
    • 1
  • M. E. Williams
    • 2
  • M. M. Harpold
    • 2
  • J. Nargeot
    • 1
  • P. Lory
    • 1
  1. 1.CRBM–CNRS, BP 5051–1919, Route de Mende, F-34033 Montpellier cedex, France Tel.: +33-4-67-613355; Fax: +33-4-67-521559; e-mail: lory@xerxes.crbm.cnrs-mop.frFR
  2. 2.SIBIA Neurosciences, Inc., 505 Coast Boulevard South, Suite 300, La Jolla, California 92037–4641, USAUS