Journal of Cancer Research and Clinical Oncology

, Volume 126, Issue 10, pp 575–583

Epidemiology and biology of human urinary bladder cancer

  • Andreas Brauers
  • Gerhard Jakse
REVIEW

DOI: 10.1007/PL00008467

Cite this article as:
Brauers, A. & Jakse, G. J Cancer Res Clin Oncol (2000) 126: 575. doi:10.1007/PL00008467

Abstract

The bladder constitutes the most frequent localization of malignant tumors in the urinary tract. Further prognostic factors are molecular and cytogenetic alterations, which have been identified as key mechanisms in the carcinogenetic pathway of bladder cancer. Structural or numerical chromosomal alterations lead to the activation of a variety of cancer-inducing oncogenes as well as to the inactivation of various distinct antiproliferative tumor-suppressor genes. With regard to the biological heterogeneity in transitional cell carcinoma, which is also reflected in epidemiological data, the differing clinical course and the limited value of established prognosticators, the analysis of new molecular parameters has become of interest in predicting the prognosis of bladder cancer patients. In addition, the definition of high-risk patient groups that are at at risk of progression and recurrence is a further objective of urological research in this field.

AbbreviationLOH loss of heterozygosity

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Andreas Brauers
    • 1
  • Gerhard Jakse
    • 1
  1. 1.University Clinic of Urology, RWTH-Aachen, Pauwelsstraße 30, D-52057, Aachen, Germany e-mail: ABrauers@aol.com Tel.: +49 241 8089374 Fax: +49 241 8888498DE