Endogenous nitric oxide and endothelin-1 in persistent pulmonary hypertension of the newborn
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We studied changes in endogenous nitric oxide (NO) synthesis and endothelin-1 (ET-1) production in infants with persistent pulmonary hypertension of the newborn (PPHN). We determined concentrations of serum NO metabolites, i.e., nitrites and nitrates (NOx), and of plasma ET-1 in five infants with PPHN (PPHN group) and in 25 healthy full-term neonates (control group). In both groups, serum NOx concentrations increased over time and plasma ET-1 concentrations decreased with age. The differences in serum NOx concentrations between groups were not significant at <12 h and 24 h of age; however, they were significantly higher in the PPHN group than in the control group at 5 days of age. The differences in plasma ET-1 concentrations between groups were not significant at 5 days of age, but were significantly higher in the PPHN group than in the control group at <12 h and 24 h of age.
Conclusion Limited endogenous nitric oxide synthesis and elevated endogenous endothelin-1 production during the first few days of life may contribute to pulmonary hypertension in infants with persistent pulmonary hypertension of the newborn.
- Endogenous nitric oxide and endothelin-1 in persistent pulmonary hypertension of the newborn
European Journal of Pediatrics
Volume 160, Issue 4 , pp 217-222
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- Key words Neonate
- Persistent pulmonary hypertension of the newborn
- Nitric oxide
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- Author Affiliations
- A1. Department of Paediatrics, Nihon University School of Medicine, Oyaguchi-Kamimachi 30-1, Itabashi-ku, Tokyo, 173-8610, Japan Tel.: +81-03-39728111 ext. 2442; Fax: +81-03-39576183, JP