Anatomy and Embryology

, Volume 203, Issue 1, pp 1–7

cDermo-1 expression indicates a role in avian skin development

  • Martin Scaal
  • Ernst-Martin Füchtbauer
  • B. Brand-Saberi
Original Article

DOI: 10.1007/PL00008244

Cite this article as:
Scaal, M., Füchtbauer, EM. & Brand-Saberi, B. Anat Embryol (2001) 203: 1. doi:10.1007/PL00008244

Abstract 

Basic helix-loop-helix (bHLH) transcription factors have been shown to be important regulatory proteins for tissue determination and differentiation. We cloned the chicken homologue of the gene of the murine Twist-related bHLH protein Dermo-1, which we named cDermo-1, and analyzed its sequence and embryonic expression. Our sequence data suggest a decisive role of Dermo-1 proteins in the evolution of amniote skin. We present a detailed analysis of cDermo-1 expression during avian embryonic development. cDermo-1 is first expressed in a variety of mesodermal tissues of the chick embryo including the limb buds, but later becomes restricted to the subectodermal mesenchyme of the integument and the developing feather buds, indicating a role of cDermo-1 during avian skin and feather development.

Keywords Dermo-1bHLHSkin developmentDermisChick

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Martin Scaal
    • 1
  • Ernst-Martin Füchtbauer
    • 2
  • B. Brand-Saberi
    • 1
  1. 1.Institute of Anatomy, University of Freiburg, Albertstrasse 17, 79104 Freiburg, Germany e-mail: brandsab@uni-freiburg.de Tel.: 761-203-5086, Fax: 761-203-5091DE
  2. 2.Max-Planck-Institute for Immunobiology, Department of Developmental Biology, Stuebeweg 51, 79108 Freiburg, GermanyDE