Botulinum toxin: evidence-based medicine criteria in blepharospasm and hemifacial spasm
- Cite this article as:
- Jost, W. & Kohl, A. J Neurol (2001) 248: I21. doi:10.1007/PL00007813
Botulinum A toxin is recognized and approved for symptomatic treatment of hemifacial spasm and blepharospasm. The state of trials is good, although double-blind placebo-controlled studies have been carried out involving only a small number of cases. Open case control studies have been done with large patient collectives. In both indications, treatment with botulinum toxin reaches the highest EBM degree in a critical evaluation.