Lung

, Volume 175 , Issue 6 , pp 379 –385

Detection of Interstitial Pneumonitis in Patients with Rheumatoid Arthritis by Measuring Circulating Levels of KL-6, a Human MUC1 Mucin

Authors

  • T.  Oyama
    • Department of Internal Medicine, Dohgo Spa Hospital, Onsen-gun, Ehime 791-02, Japan
  • N.  Kohno
    • Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime 791-02, Japan
  • A.  Yokoyama
    • Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime 791-02, Japan
  • Y.  Hirasawa
    • Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime 791-02, Japan
  • K.  Hiwada
    • Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime 791-02, Japan
  • H.  Oyama
    • Department of Internal Medicine, Dohgo Spa Hospital, Onsen-gun, Ehime 791-02, Japan
  • Y.  Okuda
    • Department of Internal Medicine, Dohgo Spa Hospital, Onsen-gun, Ehime 791-02, Japan
  • K.  Takasugi
    • Department of Internal Medicine, Dohgo Spa Hospital, Onsen-gun, Ehime 791-02, Japan

DOI: 10.1007/PL00007584

Cite this article as:
Oyama, T., Kohno, N., Yokoyama, A. et al. Lung (1997) 175: 379. doi:10.1007/PL00007584

Abstract.

In rheumatoid arthritis (RA), interstitial pneumonitis is one of the major extraarticular complications that worsens a patient's prognosis. KL-6, a human MUC1 mucin, has been reported to be a sensitive serum marker for activity of interstitial pneumonitis. We investigated the clinical significance of serum KL-6 level in patients with RA. Serum levels of KL-6 and RA-associated inflammatory markers were evaluated in 177 RA patients. The diagnosis of active interstitial pneumonitis was made by clinical symptoms, pulmonary function tests, chest X-ray film, and high resolution CT. Serum KL-6 was increased in 8 of 9 (88.9%) RA patients with active interstitial pneumonitis but in only 1 of 168 (0.6%) RA patients without active interstitial pneumonitis. No significant correlation was found between KL-6 level and conventional clinical parameters. In RA, abnormal elevation of serum KL-6 strongly indicates the complication of active interstitial pneumonitis.

Key words: Interstitial pneumonitis—Rheumatoid arthritis—KL-6.
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© 1997 Springer-Verlag New York Inc.