Acta Neuropathologica

, Volume 99, Issue 2, pp 91–95

Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer’s disease brain

  • Yasumasa Yoshiyama
  • Masato Asahina
  • Takamichi Hattori
Regular paper

DOI: 10.1007/PL00007428

Cite this article as:
Yoshiyama, Y., Asahina, M. & Hattori, T. Acta Neuropathol (2000) 99: 91. doi:10.1007/PL00007428

Abstract

A growing amount of evidence indicates that matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of Alzheimer’s disease (AD). Stromelysin-1 (MMP-3) plays a central role in activating latent-type MMPs, which are originally secreted as proenzymes. We examined MMP-3 immunoreactivity in the brains of patients who had suffered from Alzheimer’s disease and in those of neurologically normal persons. The interstitium between myelinated axons and astrocytes in the white matter of all brain tissues, and senile plaques in the gray matter of the patients with AD were stained with a monoclonal antibody to MMP-3. Comparison of the number of senile plaques stained with the antibody against MMP-3 in the parietal cortex with that in the hippocampus showed that fewer plaques were stained in the hippocampus. The selective distribution of MMP-3 in the human brain suggests that MMP-3 might play an important role in the pathogenesis of AD, especially in the degradation of β-amyloid protein.

Key words Matrix metalloproteinase-3StromelysinGlial hyaluronic acid-binding proteinAlzheimer’s ¶disease

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Yasumasa Yoshiyama
    • 1
  • Masato Asahina
    • 1
  • Takamichi Hattori
    • 1
  1. 1.Department of Neurology, School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan e-mail: yoshiyam@mx2.nisiq.net, Tel.: +81-43-2227171 ext. 5414, Fax: +81-43-2262160JP