Rheumatology International

, Volume 17, Issue 2, pp 45–48

Rapid spinal trabecular bone loss in female patients with ileitis terminalis Crohn and additional sacroiliac joint inflammation

  • J. Teichmann
  • U. Lange
  • H. Stracke
  • W. Doppl
  • H. U. Klör
  • K. Federlin
ORIGINAL ARTICLE

DOI: 10.1007/PL00006850

Cite this article as:
Teichmann, J., Lange, U., Stracke, H. et al. Rheumatology International (1997) 17: 45. doi:10.1007/PL00006850

Abstract

Patients with Crohn's disease are well known to have local and generalized osteopenia of varying degrees. The aim of this study was to investigate whether the additional involvement of the sacroiliac joint as an extra-intestinal manifestation has an influence on bone turnover in female patients with Crohn's disease. Osteocalcin and other parameters of bone metabolism were measured in 79 female patients with Crohn's disease. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DEXA). Z scores were obtained by comparison with age- and sex-matched normal values. As regards the sacroiliac involvement (n = 26; group 1), we found a significantly lower BMD in the lumbar spine (L4) and in Ward's triangle of the femoral neck compared to controls (P < 0.05) and those patients (n = 53; group 2) with pure ileitis terminalis Crohn. Furthermore, the duration of the disease process in patients with Crohn's disease and extra-intestinal involvement was markedly shorter than that of patients in group 2 (P < 0.05). In conclusion, osteoporosis in female patients with sacroiliac involvement manifested itself in a more severe way.

Key words Ileitis terminalis CrohnBone lossSacroiliitis

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. Teichmann
    • 1
  • U. Lange
    • 1
  • H. Stracke
    • 1
  • W. Doppl
    • 1
  • H. U. Klör
    • 1
  • K. Federlin
    • 1
  1. 1.Medizinische Klinik III und Poliklinik, Justus-Liebig-Universität Giessen, Rodthol 9, 35385 Giessen, Germany, Tel./Fax. 0641-702-3700/3752DE