Journal of Molecular Evolution

, Volume 48, Issue 2, pp 213–217

On Negative Selection Against ATG Triplets Near Start Codons in Eukaryotic and Prokaryotic Genomes

Authors

  • Rintaro  Saito
    • Laboratory for Bioinformatics, Keio University, Endo 5322, Fujisawa, Kanagawa 252-8520, Japan
  • Masaru  Tomita
    • Laboratory for Bioinformatics, Keio University, Endo 5322, Fujisawa, Kanagawa 252-8520, Japan
Article

DOI: 10.1007/PL00006460

Cite this article as:
Saito, R. & Tomita, M. J Mol Evol (1999) 48: 213. doi:10.1007/PL00006460

Abstract.

The frequencies of ATG triplets in the genomes of various species were systematically analyzed, and the frequency of ATG triplets was significantly low around start codons in both prokaryotic and eukaryotic genomes. In eukaryotes, however, the frequency decrease before the start codon is much more evident than that after the start codon. In prokaryotes, on the other hand, the ATG frequency pattern around the start codon is less evident, and—more importantly—symmetric.

We also computed average distances between a start codon and its nearest upstream-located ATG triplet and found a general tendency for the average distances to be longer in higher organisms.

Key words: Translation initiation — Start codon — AUG triplets — Triplet frequency — Untranslated region — Negative selection

Copyright information

© Springer-Verlag New York Inc. 1999