Journal of Molecular Evolution

, Volume 46, Issue 1, pp 84–101

Evolution of Substrate Specificities in the P-Type ATPase Superfamily

  • Kristian B.  Axelsen
  • Michael G.  Palmgren

DOI: 10.1007/PL00006286

Cite this article as:
Axelsen, K. & Palmgren, M. J Mol Evol (1998) 46: 84. doi:10.1007/PL00006286


P-type ATPases make up a large superfamily of ATP-driven pumps involved in the transmembrane transport of charged substrates. We have performed an analysis of conserved core sequences in 159 P-type ATPases. The various ATPases group together in five major branches according to substrate specificity, and not according to the evolutionary relationship of the parental species, indicating that invention of new substrate specificities is accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized family of P-type ATPases has been identified that is expected to be represented in all the major phyla of eukarya.

Key words: Na+— K+— Cu2+— H+— Mg2+— Cd2+— Phospholipid translocases 

Copyright information

© Springer-Verlag New York Inc. 1998

Authors and Affiliations

  • Kristian B.  Axelsen
    • 1
  • Michael G.  Palmgren
    • 1
  1. 1.Department of Plant Physiology, Institute of Molecular Biology, Copenhagen University, Øster Farimagsgade 2A, DK-1353 Copenhagen K, DenmarkDK
  2. 2.Department of Plant Biology, Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871 Frederiksberg C, DenmarkDK