, 44:S78

Vascular disease in younger-onset diabetes: comparison of European, Asian and American Indian cohorts of the WHO multinational study of vascular disease in diabetes

  • E. T. Lee
  • M. Lu
  • P. H. Bennett
  • H. Keen
  • and the WHO Multinational Study Group

DOI: 10.1007/PL00002943

Cite this article as:
Lee, E., Lu, M., Bennett, P. et al. Diabetologia (2001) 44(Suppl 2): S78. doi:10.1007/PL00002943



This study compared the incidence of vascular disease in subjects with younger-onset diabetes from different ethnic groups.


The incidence of vascular disease end-points has been studied in a sub-group (n = 994) of participants of the World Health Organization Multinational Study of Vascular Disease in Diabetes (WHO MSVDD) who had younger-onset diabetes (diagnosed before the age of 30 years). The study participants have been divided into European (n = 631), Asian (n = 84) and American Indian (n = 91) cohorts.


For Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus, American Indian men had a higher incidence of lower-extremity amputation and renal failure than the other cohorts, whereas European women had a higher incidence of angina than other cohorts. American Indians also had a higher incidence of any retinopathy, clinical proteinuria and albuminuria than the European and Asian cohorts.


This study confirms the high burden of large and small-vessel disease complications manifest in American Indian people with younger-onset diabetes. [Diabetologia (2001) 44 [Suppl 2]: S 78–S 81]


Type I (insulin-dependent) diabetes mellitus Type II (non-insulin-dependent) diabetes mellitus Ethnic differences Cardiovascular disease Amputation Retinopathy Nephropathy 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • E. T. Lee
    • 1
  • M. Lu
    • 1
  • P. H. Bennett
    • 2
  • H. Keen
    • 3
  • and the WHO Multinational Study Group
  1. 1.Centre for American Indian Health Research and Department of Biostatistics and Epidemiology, College of Public HealthUniversity of Oklahoma Health Sciences CentreOklahoma CityUSA
  2. 2.NIDDKPhoenix Epidemiology and Clinical Research BranchPhoenixUSA
  3. 3.Unit for Metabolic MedicineGuy's HospitalLondonUK

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