Article

Diabetologia

, 44:S78

First online:

Vascular disease in younger-onset diabetes: comparison of European, Asian and American Indian cohorts of the WHO multinational study of vascular disease in diabetes

  • E. T. LeeAffiliated withCentre for American Indian Health Research and Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Centre
  • , M. LuAffiliated withCentre for American Indian Health Research and Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Centre
  • , P. H. BennettAffiliated withNIDDK, Phoenix Epidemiology and Clinical Research Branch
  • , H. KeenAffiliated withUnit for Metabolic Medicine, Guy's Hospital
  • , and the WHO Multinational Study Group

Abstract.

Aims/hypothesis:

This study compared the incidence of vascular disease in subjects with younger-onset diabetes from different ethnic groups.

Methods:

The incidence of vascular disease end-points has been studied in a sub-group (n = 994) of participants of the World Health Organization Multinational Study of Vascular Disease in Diabetes (WHO MSVDD) who had younger-onset diabetes (diagnosed before the age of 30 years). The study participants have been divided into European (n = 631), Asian (n = 84) and American Indian (n = 91) cohorts.

Results:

For Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus, American Indian men had a higher incidence of lower-extremity amputation and renal failure than the other cohorts, whereas European women had a higher incidence of angina than other cohorts. American Indians also had a higher incidence of any retinopathy, clinical proteinuria and albuminuria than the European and Asian cohorts.

Conclusion/interpretation:

This study confirms the high burden of large and small-vessel disease complications manifest in American Indian people with younger-onset diabetes. [Diabetologia (2001) 44 [Suppl 2]: S 78–S 81]

Keywords

Type I (insulin-dependent) diabetes mellitus Type II (non-insulin-dependent) diabetes mellitus Ethnic differences Cardiovascular disease Amputation Retinopathy Nephropathy