Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 8, pp 1045–1053

Neurotrophin signalling pathways regulating neuronal apoptosis

  • F.D. Miller
  • D.R. Kaplan

DOI: 10.1007/PL00000919

Cite this article as:
Miller, F. & Kaplan, D. CMLS, Cell. Mol. Life Sci. (2001) 58: 1045. doi:10.1007/PL00000919

Abstract:

Recent evidence indicates that naturally occurring neuronal death in mammals is regulated by the interplay between receptor-mediated prosurvival and proapoptotic signals. The neurotrophins, a family of growth factors best known for their positive effects on neuronal biology, have now been shown to mediate both positive and negative survival signals, by signalling through the Trk and p75 neurotrophin receptors, respectively. The mechanisms whereby these two neurotrophin receptors interact to determine neuronal survival have been difficult to decipher, largely because both can signal independently or coincidentally, depending upon the cell or developmental context. Nonetheless, the past several years have seen significant advances in our understanding of this receptor signalling system. In this review, we focus on the proapoptotic actions of the p75 neurotrophin receptor (p75NTR), and on the interplay between Trk and p75NTR that determines neuronal survival.

Key words: Neurotrophin; Trk receptor; p75 neurotrophin receptor; neuronal apoptosis; p53; p73; JNK; sympathetic neuron; neuronal signal transduction; neuronal cell cycle.

Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • F.D. Miller
    • 1
  • D.R. Kaplan
    • 1
  1. 1.Center for Neuronal Survival, Montreal Neurological Institute, 3801 rue University, Montreal, PQ H3A 2B4 (Canada), Fax +1 514 398 1319, e-mail: mdfm@musica.mcgill.ca CA