, Volume 58, Issue 8, pp 1014-1020

Genes for neurotrophic factors and their receptors: structure and regulation

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Neurotrophins and their receptors have attracted much interest during the last two decades. Although the mode of action of molecules of the neurotrophin system has been studied extensively, information on molecular mechanisms governing their expression is mosaic and incomplete. This review attempts to summarize the data available on gene structure and transcriptional regulation of neurotrophins and their receptors, and outlines perspectives for the future in this field.