Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 7, pp 902–920

Multifunctional α-enolase: its role in diseases

  • V. Pancholi

DOI: 10.1007/PL00000910

Cite this article as:
Pancholi, V. CMLS, Cell. Mol. Life Sci. (2001) 58: 902. doi:10.1007/PL00000910

Abstract.

Enolase, a key glycolytic enzyme, belongs to a novel class of surface proteins which do not possess classical machinery for surface transport, yet through an unknown mechanism are transported on the cell surface. Enolase is a multifunctional protein, and its ability to serve as a plasminogen receptor on the surface of a variety of hematopoetic, epithelial and endothelial cells suggests that it may play an important role in the intravascular and pericellular fibrinolytic system. Its role in systemic and invasive autoimmune disorders was recognized only very recently. In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes.

Key words.Enolase; autoimmunity; rheumatic fever; SLE.

Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • V. Pancholi
    • 1
  1. 1.Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York (New York 10021, USA), Fax +1 212 327 7584, e-mail: panchov@rockvax.rockefeller.eduUS