The role of Sonic hedgehog in neural tube patterning
- I. PattenAffiliated withMRC Intercellular Signalling Group, Developmental Genetics Programme, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom), e-mail: firstname.lastname@example.org
- , M. Placzek*Affiliated withMRC Intercellular Signalling Group, Developmental Genetics Programme, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom), e-mail: email@example.com
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In the developing neural tube of vertebrate embryos, many types of neural and nonneuronal cells differentiate in response to the secreted signalling molecule, Shh. Shh shows a spatially restricted pattern of expression in cells located at the ventral midline, yet governs the differentiation of diverse cell types throughout the ventral half of the neural tube. Here, we describe how the distinct fate assumed by cells in response to Shh is dependent upon their position with respect to both the dorso-ventral and anterior-posterior axes of the neural tube and describe the ways in which a single factor, Shh, is able to pattern the developing nervous system. We first discuss the evidence that Shh does impose ventral identity on cells in the neural tube, then focus on the role of a graded Shh signal in patterning the neural tube and finally discuss the interaction of Shh with other factors that affect its signalling outcome.
- The role of Sonic hedgehog in neural tube patterning
Cellular and Molecular Life Sciences CMLS
Volume 57, Issue 12 , pp 1695-1708
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- Birkhäuser Verlag
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- Key words. Neural tube; development; neural cell differentiation.
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