Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 11, pp 1551–1561

The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy

Authors

  • D.M. Kullmann
    • University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG (United Kingdom)
  • F. Asztely
    • Section of Restorative Neurology, Wallenberg Neuroscience Center, Department of Clinical Neuroscience, Lund University Hospital, Lund S-221 85 (Sweden)
  • M.C. Walker
    • University Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG (United Kingdom)

DOI: 10.1007/PL00000640

Cite this article as:
Kullmann, D., Asztely, F. & Walker, M. CMLS, Cell. Mol. Life Sci. (2000) 57: 1551. doi:10.1007/PL00000640

Abstract.

Synaptic plasticity is the foremost candidate mechanism to explain the rapid acquisition of memories. In the mammalian brain, the NMDA subclass of glutamate receptors plays a central role in the induction of several forms of use-dependent plasticity. The finding that modifications in synaptic strength are largely expressed by receptors of the AMPA subclass has focused attention on molecular mechanisms that affect their function and targeting. Receptor plasticity has also been reported in pathological situations, notably in animal and human forms of epilepsy. Which of these changes are causally implicated in the generation of seizures, and which may be compensatory or neuroprotective adaptations, has not been fully resolved.

Key words. AMPA; NMDA; kainate; GABA; receptor subunits; phosphorylation; silent synapses; status epilepticus.

Copyright information

© Birkhäuser Verlag Basel, 2000