Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 10, pp 1388–1398

COUP-TF orphan nuclear receptors in development and differentiation

  • F. A. Pereira
  • M. J. Tsai
  • S. Y. Tsai*

DOI: 10.1007/PL00000624

Cite this article as:
Pereira, F., Tsai, M. & Tsai*, S. CMLS, Cell. Mol. Life Sci. (2000) 57: 1388. doi:10.1007/PL00000624
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Abstract.

Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. They have been shown to negatively regulate the activation function of vitamin D, thyroid hormone, retinoic acid, the retinoid X and the peroxisome proliferator-activated receptors. COUP-TF genes have been cloned from many species and their sequences are exceptionally conserved through evolution. This suggests a critical role for the COUP-TFs in these organisms. Indeed, the Drosophila COUP-TF, seven-up and mouse COUP-TFII are essential for development and differentiation during embryogenesis. Our current understanding of COUP-TF function suggests that they serve vital physiological roles during development despite extensive overlaps of expression. This defines the COUP-TFs as important factors in regulation of development and differentiation in multiple organisms.

Key words. Orphan nuclear receptors; COUP-TF; embryogenesis. 

Copyright information

© Birkhäuser Verlag Basel, 2000

Authors and Affiliations

  • F. A. Pereira
    • 1
  • M. J. Tsai
    • 2
  • S. Y. Tsai*
    • 1
  1. 1.Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, (USA). Fax +713 798 8227, e-mail:stsai@bcm.tmc.eduUS
  2. 2.Department of Medicine Baylor College of Medicine, Houston (Texas 77030, USA)US

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