Inflammation Research

, Volume 50, Issue 12, pp 585–591

Estrogens ameliorate remote organ inflammation induced by burn injury in rats

  • E.S. Özveri
  • A. Bozkurt
  • G. Haklar
  • Ş. Çetinel
  • S. Arbak
  • C. Yeğen
  • B.Ç. Yeğen

DOI: 10.1007/PL00000238

Cite this article as:
Özveri, E., Bozkurt, A., Haklar, G. et al. Inflamm. res. (2001) 50: 585. doi:10.1007/PL00000238
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Abstract.

Objective and design: The present study was designed to investigate the role of sex steroids in burn-induced remote organ injury.¶Material or subjects: Male Wistar albino rats were given burn trauma (n=39), and underwent castration or sham operation at 2 h following the burn injury.¶Treatment: Rats were injected sc with either 17β estradiol benzoate (E2, 10 mg/kg) or an androgen receptor blocker cyproterone acetate (CPA, 25 mg/kg) or vehicle, immediately after burn and at 12 h.¶Methods: At 24 h of burn insult, rats were decapitated. Blood samples for RIA of testosterone, estradiol and tumor necrosis factor (TNF)-α and the tissue samples for myeloperoxidase activitiy (MPO) were taken. ANOVA student's t test was used for statistical analysis.¶Results: Castration, antiandrogen and E2 treatments increased plasma estradiol levels and depressed burn-induced elevation in serum TNF-α levels. In the liver and lung, burn-induced increase in MPO was reduced by E2 and castration, while CPA was effective in reducing neutrophil infiltration only in the liver.¶Conclusion: We propose that treatment with estrogens or antiandrogens might be applicable in clinical situations to ameliorate systemic inflammation induced by burn.

Key words: Castration - Androgen depletion - Estradiol - Myeloperoxidase activity 

Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • E.S. Özveri
    • 1
  • A. Bozkurt
    • 2
  • G. Haklar
    • 3
  • Ş. Çetinel
    • 4
  • S. Arbak
    • 4
  • C. Yeğen
    • 1
  • B.Ç. Yeğen
    • 2
  1. 1.Marmara University Hospital, Dept of General Surgery, Altunizade, TR-81190, Istanbul, Turkey TR
  2. 2.Marmara University School of Medicine, Department of Physiology, Haydarpaşa, TR-81326, Istanbul, Turkey, Fax: ++ 90 216 418 33 27, e-mail: yegen@superonline.com / tarcin@superonline.com TR
  3. 3.Marmara University School of Medicine, Dept of Biochemistry, Haydarpaşa, TR-81326, Istanbul, Turkey TR
  4. 4.Marmara University School of Medicine, Dept of Histology & Embryology, Haydarpaşa, TR-81326, Istanbul, Turkey TR

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