Estrogens ameliorate remote organ inflammation induced by burn injury in rats
- Cite this article as:
- Özveri, E., Bozkurt, A., Haklar, G. et al. Inflamm. res. (2001) 50: 585. doi:10.1007/PL00000238
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Objective and design: The present study was designed to investigate the role of sex steroids in burn-induced remote organ injury.¶Material or subjects: Male Wistar albino rats were given burn trauma (n=39), and underwent castration or sham operation at 2 h following the burn injury.¶Treatment: Rats were injected sc with either 17β estradiol benzoate (E2, 10 mg/kg) or an androgen receptor blocker cyproterone acetate (CPA, 25 mg/kg) or vehicle, immediately after burn and at 12 h.¶Methods: At 24 h of burn insult, rats were decapitated. Blood samples for RIA of testosterone, estradiol and tumor necrosis factor (TNF)-α and the tissue samples for myeloperoxidase activitiy (MPO) were taken. ANOVA student's t test was used for statistical analysis.¶Results: Castration, antiandrogen and E2 treatments increased plasma estradiol levels and depressed burn-induced elevation in serum TNF-α levels. In the liver and lung, burn-induced increase in MPO was reduced by E2 and castration, while CPA was effective in reducing neutrophil infiltration only in the liver.¶Conclusion: We propose that treatment with estrogens or antiandrogens might be applicable in clinical situations to ameliorate systemic inflammation induced by burn.