Review Article

Journal of Endocrinological Investigation

, Volume 27, Issue 1, pp 96-98

Peripheral regulation of food intake: New insights

  • O. UkkolaAffiliated withDepartment of Internal Medicine and Biocenter Oulu, University of Oulu Email author 

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Appetite is controlled by a complicated system with hunger and satiety signals interacting in complex pathways both peripherally and centrally. Insulin, leptin and ghrelin are key hormonal regulators of food intake. Ghrelin enhances appetite while leptin is a satiety signal. A novel peripheral regulator of food intake, peptide YY3–36, is released from the gastrointestinal tract postprandially. In this review old and new peripheral signals and their interaction in the control of food intake are briefly discussed.


Insulin leptin ghrelin peptide YY3–36