Review Article

Journal of Endocrinological Investigation

, Volume 30, Issue 11, pp 962-976

Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa

  • A. TorselloAffiliated withDepartment of Experimental Medicine, University of Milano-BicoccaInterdepartmental Center for Bioinformatics and Proteomics, University of Milano-Bicocca Email author 
  • , F. BrambillaAffiliated withDepartment of Mental Health, Sacco Hospital
  • , L. TamiazzoAffiliated withDepartment of Experimental Medicine, University of Milano-Bicocca
  • , I. BulgarelliAffiliated withDepartment of Experimental Medicine, University of Milano-Bicocca
  • , D. RapettiAffiliated withDepartment of Experimental Medicine, University of Milano-Bicocca
  • , E. BrescianiAffiliated withDepartment of Experimental Medicine, University of Milano-Bicocca
  • , V. LocatelliAffiliated withDepartment of Experimental Medicine, University of Milano-BicoccaInterdepartmental Center for Bioinformatics and Proteomics, University of Milano-Bicocca

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Abstract

In the last decades we have come to understand that the hypothalamus is a key region in controlling energy homeostasis. A number of control models have been proposed to explain the regulation of feeding behavior in physiological and pathological conditions, but all those based on imbalances of single factors fail to explain the disrupted regulation of energy supply in eating disorders such as anorexia nervosa and bulimia nervosa, as well as other psychiatric disorders. A growing amount of evidence demonstrates that many signaling molecules originated within the brain or coming from the adipose tissue or the gastro-enteric tract are involved in the highly complex process controlling food intake and energy expenditure. The recent discovery of leptin, ghrelin, and other factors have made it possible to penetrate in the still undefined pathophysiology of eating disorders with the hope of finding effective treatments for such diseases.

Key-words

Appetite body weight gut hormones CNS eating disorders