Journal of Endocrinological Investigation

, Volume 28, Issue 11, pp 853–863

Type 2 diabetes mellitus in children and adolescents

Review Article

DOI: 10.1007/BF03347581

Cite this article as:
Marcovecchio, M., Mohn, A. & Chiarelli, F. J Endocrinol Invest (2005) 28: 853. doi:10.1007/BF03347581


Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Prevalence of T2DM in children is mostly linked to some risk factors: obesity and sedentary lifestyle, puberty, membership of ethnic minorities, features of insulin resistance, family history of T2DM, female gender and perinatal factors. Prevention is essential and can be considered a public health approach directed to the general population. Treatment of T2DM in youth is complex and based on different strategies: diet, exercise and pharmacotherapy. An appropriated intervention program must be started early, in order to prevent or retard the progression of the disease and associated comorbidities.


T2DMinsulin resistancechildrenadolescentsyouth

Copyright information

© Italian Society of Endocrinology (SIE) 2005

Authors and Affiliations

  1. 1.Department of PediatricsUniversity of ChietiChietiItaly