Journal of Endocrinological Investigation

, Volume 30, Issue 8, pp 653–658

Low 25-hydroxyvitamin D concentrations in obese women: Their clinical significance and relationship with anthropometric and body composition variables

  • N. Vilarrasa
  • J. Maravall
  • A. Estepa
  • R. Sánchez
  • C. Masdevall
  • M. A. Navarro
  • P. Alía
  • J. Soler
  • J. M. Gómez
Original Articles

DOI: 10.1007/BF03347445

Cite this article as:
Vilarrasa, N., Maravall, J., Estepa, A. et al. J Endocrinol Invest (2007) 30: 653. doi:10.1007/BF03347445
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Abstract

Obesity is associated with low concentrations of 25-hydroxyvitamin D [25(OH) D]. However, conflicting results have been found regarding the relationship of 25(OH) D with anthropometric and adiposity parameters. The aim of our study was to analyze the association between 25(OH) D and body fat (BF) in a homogeneous cohort of non-obese, obese, and morbidly obese Caucasian women. The study was performed in L’Hospitalet de Llobregat, a city adjacent to Barcelona with a latitude of 41 degrees, 22 minutes, and 5 seconds north. Materials and methods: Plasma concentrations of 25(OH) D were determined and body composition was evaluated by bioelectrical impedance in a group of 43 women with morbid obesity, 28 non-morbidly obese, and 50 non-obese women matched for age. Results: Morbidly obese women showed lower 25(OH) D concentrations compared to non-morbidly and non-obese women (37.9±16 vs 40.2±13 vs 56.7±21 nmol/l, p=0.001). Fifty-one percent of morbidly obese women had vitamin D deficiency [25(OH) D<38 nmol/l] compared to 22% of non-obese patients, (p=0.004). In the bivariate correlation analysis 25(OH) D was inversely associated with weight (r=−0.41, p=0.001), body mass index (BMI) (r=−0.432, p=0.001 ), waist to hip ratio (WHR)(r=−0.40, p=0.001 ), BF (r=−0.53, p=0001 ), fat mass (r=−0.44, p=0.0001), fat-free mass (r=−0.35, p=0.001). In the multivariate general linear model analysis, 25(OH) D was associated with season of examination (p=0.001) and was negatively associated with BF (β=−0.75, p=0.001), after adjusting for age, BMI, and WHR. Conclusions: 25(OH) D concentrations are associated with body composition variables especially by BF, independently of seasonal variability. Therefore, body adiposity should be considered when assessing vitamin D requirements in obese patients.

Key-words

Obesity body fat fat mass calcidiol vitamin D 

Copyright information

© Italian Society of Endocrinology (SIE) 2007

Authors and Affiliations

  • N. Vilarrasa
    • 1
  • J. Maravall
    • 1
  • A. Estepa
    • 1
  • R. Sánchez
    • 2
  • C. Masdevall
    • 2
  • M. A. Navarro
    • 3
  • P. Alía
    • 3
  • J. Soler
    • 1
  • J. M. Gómez
    • 1
  1. 1.Endocrinology and Diabetes UnitBellvitge Universitary HospitalBarcelonaSpain
  2. 2.Department of Bariatric SurgeryBellvitge Universitary HospitalBarcelonaSpain
  3. 3.Department of BiochemistryBellvitge Universitary HospitalBarcelonaSpain
  4. 4.L’Hospitalet de LlobregatBarcelonaSpain

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