Original Articles

Journal of Endocrinological Investigation

, Volume 34, Issue 1, pp 16-20

First online:

No association of obesity gene FTO with body composition at the age of 6 months. The Generation R Study

  • D. O. Mook-KanamoriAffiliated withThe Generation R Study Group, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Pediatrics, Erasmus Medical Center
  • , L. AyAffiliated withThe Generation R Study Group, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Pediatrics, Erasmus Medical Center
  • , A. HofmanAffiliated withDepartment of Epidemiology, Erasmus Medical Center
  • , C. M. van DuijnAffiliated withDepartment of Epidemiology, Erasmus Medical Center
  • , H. A. MollAffiliated withDepartment of Pediatrics, Erasmus Medical Center
  • , H. RaatAffiliated withDepartment of Public Health, Erasmus Medical Center
  • , A. C. S. Hokken-KoelegaAffiliated withDepartment of Pediatrics, Erasmus Medical Center
  • , V. W. V. JaddoeAffiliated withThe Generation R Study Group, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Pediatrics, Erasmus Medical Center Email author 

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Abstract

Background: Genome-wide association studies on body mass index (BMI) have identified an FTO polymorphism (rs9939609) as having the strongest effect. Aim: We examined the effect of FTO genotype on body composition at the age of 6 months using skinfold thickness measurements and dual energy X-ray absorptiometry (DXA). Material/subjects and methods: This study was embedded in a population-based prospective cohort study from early fetal life onwards. FTO genotype was related to anthropometric measurements (weight and height), subcutaneous fat mass measured by skinfold thickness, and total, truncal, and peripheral fat mass and lean mass measured by DXA. Analyses for skinfold thickness and DXA were performed in 695 and 216 children, respectively. Results: Genotype frequency was TT 40.3%, TA 45.5%, and AA 14.2%. No significant differences between FTO genotypes were found in weight, height or BMI. Furthermore, FTO genotype was not associated with any skinfold thickness. Finally, no associations between FTO genotype and body composition measures (fat and lean mass) assessed by DXA were found. Conclusions: We observed no association between this FTO polymorphism and body composition at the age of 6 months. Longer follow-up studies are necessary to examine at which age and by which mechanisms FTO genotype starts to influence fat mass and body composition.

Keywords

Body Composition DXA-scan infancy obesity gene FTO skinfold thickness