Journal of Endocrinological Investigation

, Volume 31, Issue 12, pp 1098–1102

High-normal fasting glucose levels are associated with increased prevalence of impaired glucose tolerance in obese children

  • A. Grandone
  • A. Amato
  • C. Luongo
  • N. Santoro
  • L. Perrone
  • E. Miraglia del Giudice
Original Articles

DOI: 10.1007/BF03345659

Cite this article as:
Grandone, A., Amato, A., Luongo, C. et al. J Endocrinol Invest (2008) 31: 1098. doi:10.1007/BF03345659

Abstract

The natural history of impaired glucose tolerance (IGT) and Type 2 diabetes among obese children is not clear. Although the cut-off for impaired fasting glucose (IFG) has recently been changed from 110 (6.1 mmol/l) to 100 mg/dl (5.6 mmol/l), it does not seem a reliable way to find all subjects with impaired glucose homeostasis. The aim of our study was to determine whether high-normal fasting glucose level could predict the occurrence of IGT and metabolic syndrome. Three hundred and twenty-three Italian obese children and adolescents were included in the study (176 females, mean age 11±2.9 yr; mean body mass index z-score: 3±0.6). Waist circumference, serum glucose, insulin, triglyceride, cholesterol HDL, blood pressure were evaluated and an oral glucose tolerance test (OGTT) was performed. The prevalence of IFG and IGT were respectively 1.5% (5 subjects) and 5% (18 patients); no diabetic patients were found. Metabolic syndrome was diagnosed in 20% of patients. Fasting glycemia values <100 mg/dl (5.6 mmol/l) have been divided in quintiles. Metabolic syndrome prevalence increased across quintiles, although not in a statistically significantly manner, but it could depend on the selected diagnostic criteria as no univocal definition exists for metabolic syndrome in youths. Interestingly high-normal fasting plasma glucose levels constitute an independent risk factor for IGT among obese children and adolescents; therefore, this very easy-to-use parameter may help to identify obese patients at increased risk of diabetes or at least could suggest in which subjects to perform an OGTT.

Keywords

Childrenfasting plasma glucoseimpaired glucose toleranceobesitytype 2 diabetes

Copyright information

© Italian Society of Endocrinology (SIE) 2008

Authors and Affiliations

  • A. Grandone
    • 1
  • A. Amato
    • 1
  • C. Luongo
    • 1
  • N. Santoro
    • 1
  • L. Perrone
    • 1
  • E. Miraglia del Giudice
    • 1
  1. 1.Dipartimento di PediatriaSeconda Universitá di NapoliNapoliItaly