Journal of Endocrinological Investigation

, Volume 34, Issue 7, pp 534–540

Clinical characteristics and incidence of first fracture in a consecutive sample of post-menopausal women attending osteoporosis centers: The PROTEO-1 study

Authors

    • Gerontology Section, Department of Surgical and Medical DisciplinesUniversity of Turin
  • V. Braga
    • Rheumatology Unit, Department of Biomedical and Surgical SciencesUniversity of Verona
  • S. Minisola
    • Department of Clinical SciencesII Clinica Medica
  • G. Bianchi
    • Rheumatology Unit
  • A. Del Puente
    • Department of Clinical and Experimental MedicineFederico II University of Naples
  • L. Di Matteo
    • Rheumatology UnitPescara Hospital
  • G. Pagano Mariano
    • Rheumatology UnitHospital Bianchi-Melacrini-Morelli Reggio Calabria
  • V. M. Latte
    • Center for Osteoporosis Prevention and CareSan Paolo Hospital
  • F. D’Amico
    • Gerontology UnitHospital “B.Romeo”
  • C. Bonali
    • Rheumatology UnitHospital, Policlinico Consorziale
  • P. D’Amelio
    • Gerontology Section, Department of Surgical and Medical DisciplinesUniversity of Turin
Original Articles

DOI: 10.1007/BF03345393

Cite this article as:
Isaia, G.C., Braga, V., Minisola, S. et al. J Endocrinol Invest (2011) 34: 534. doi:10.1007/BF03345393

Abstract

Background: Osteoporosis is a highly prevalent disease and fractures are a major cause of disability and morbidity. Aim: The purpose of this study was to characterize post-menopausal women attending osteoporosis centers in Italy, to evaluate physician management, and to determine the incidence of first osteoporotic fracture. Subjects and methods: PROTEO-1 was an observational longitudinal study with a 12-month follow-up. Data were collected from women attending osteoporosis centers. Women without prevalent fracture were eligible to enter the 1-yr follow-up phase: the clinical approach to patients according to their fracture risk profile and the incidence of fracture were recorded. Results: 4269 patients were enrolled in 80 centers in the cross-sectional phase; 34.2% had an osteoporotic fracture at baseline. Patients with prevalent fractures were older and more likely to be treated compared with non-fractured patients. The incidence of vertebral or hip fracture after 1 yr was 3.84%, regardless of the calculated risk factor profile, and was significantly higher in patients with back pain at baseline (4.2%) compared with those without back pain (2.2%; p=0.023). Generally, physicians prescribed more blood exams and drugs to patients at higher risk of fracture. Among fractured patients only 24% were properly treated; the rate of non-responders to treatment was about 4%. Conclusions: In a large, unselected sample of post-menopausal women attending osteoporosis centers, those without previous fracture were at substantial risk of future fracture, regardless of their theoretical low 10-yr fracture risk. The presence of back pain in women without previous fracture warrants close attention.

Key-words

Fractureosteoporosisrisk factorsSIOMMMS algorithm

Copyright information

© Italian Society of Endocrinology (SIE) 2011