Rapid Communication

Journal of Endocrinological Investigation

, Volume 29, Issue 8, pp RC13-RC15

First online:

Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats

  • L. M. SeoaneAffiliated withEndocrinología Molecular, Área de Investigación, Complejo Hospitalario Universitario de Santiago (CHUS) Email author 
  • , O. Al-MassadiAffiliated withDepartment of Medicine, Santiago de Compostela University
  • , Y. PazosAffiliated withEndocrinología Molecular, Área de Investigación, Complejo Hospitalario Universitario de Santiago (CHUS)
  • , U. PagottoAffiliated withEndocrinology Unit, Sant’Orsola-Malpighi Hospital
  • , F. F. CasanuevaAffiliated withEndocrinología Molecular, Área de Investigación, Complejo Hospitalario Universitario de Santiago (CHUS)Department of Medicine, Santiago de Compostela University

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Abstract

The isolation of ghrelin unveiled a new system implicated in food intake regulation. The recently isolated hormone obestatin derives from the same precursor of ghrelin and seems to perform opposite actions. It could be part of a dual system connecting gut and brain to regulate energy homeostasis. The ability of intracerebroventricular administration of obestatin to modify food intake was evaluated. Obestatin had no effect on spontaneous food intake in both ad libitum and food restricted rats. The obestatin injection was not able to antagonize the ghrelin-stimulated increase in food intake either. In conclusion, the present work does not support a role for obestatin on the regulation of food intake in any model studied.

En]Keywords

Obestatin ghrelin food-intake energy homeostasis appetite