Original Article

Journal of Endocrinological Investigation

, Volume 23, Issue 8, pp 509-514

Circulating interleukin-6 significantly correlates to thyroid hormone in acute myocardial infarction but not in chronic heart failure

  • M. NishinoAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , T. KimuraAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , T. KandaAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine Email author 
  • , N. KotajimaAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , A. YoshidaAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , A. KuwabaraAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , K. TamamaAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , Y. FukumuraAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine
  • , I. KobayashiAffiliated withDepartment of Laboratory Medicine, Gunma University School of Medicine

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

To investigate relationships between thyroid states and the cardiac endocrine system, we analyzed thyrotropin (TSH), thyroid hormone, plasma levels of interleukin-6 (IL-6) and brain natriuretic peptide (BNP) in 50 patients with chronic heart failure (CHF), in 30 patients with heart failure from acute myocardial infarction (AMI), and in 15 controls. Plasma levels of IL-6 and BNP in both CHF and AMI were significantly elevated, while free triiodothyronine (FT3) was significantly decreased compared to controls. FT3/ free thyroxine (FT4) ratio was significantly decreased in CHF but not in AMI compared to controls. In CHF, diuretic treatment diminished circulating BNP but not IL-6, while diuretic treatment increased FT3/FT4 ratio. In AMI, FT3/ FT4 ratio was significantly decreased 72h compared to 12h after the onset of AMI, while BNP and IL-6 were significantly increased 72h compared to 12h after the onset of AMI. In both CHF and AMI, BNP significantly correlated with FT4. On the other hand, significant correlations between IL-6 and FT3, and between IL-6 and FT3/FT4 ratio were detected in AMI but not in CHF. This preliminary study suggests that IL-6, BNP and thyroid hormone reflect ventricular dysfunction in both acute and chronic heart failure, and that IL-6 significantly relates to circulating thyroid hormone in AMI but not in CHF.

Key-words

Interleukin-6 (IL-6) thyrotropin (TSH) free triiodothyronine (FT3) free thyroxine (FT4) chronic heart failure (CHF) acute myocardial infarction (AMI) brain natriuretic peptide (BNP) euthyroid sick syndrome (ESS)