Obesity Surgery

, Volume 14, Supplement 1, pp S33–S39

Progress in Implantable Gastric Stimulation: Summary of Results of the European Multi-Center Study

  • Maurizio De Luca
  • Gianni Segato
  • Luca Busetto
  • Franco Favretti
  • Franz Aigner
  • Helmut Weiss
  • Charles de Gheldere
  • Giorgio Gaggiotti
  • Jacques Himpens
  • Jorge Limao
  • Matthias Scheyer
  • Mauro Toppino
  • Ernst L. Zurmeyer
  • Giorgio Bottani
  • Heinrich Penthaler
Article

DOI: 10.1007/BF03342136

Cite this article as:
De Luca, M., Segato, G., Busetto, L. et al. OBES SURG (2004) 14(Suppl 1): S33. doi:10.1007/BF03342136

Abstract

Background

The Implantable Gastric Stimulator (IGS®), a pacemaker-like device, has been found to be safe and effective to induce and maintain weight loss. The LOSS (Laparoscopic Obesity Stimulation Survey) is a prospective non-randomized trial which enrolled 69 patients involving 11 investigator centers in 5 European Countries. In 19 patients, ghrelin was analyzed.

Methods

Between January 2002 and December 2003, 69 patients (F/M 49/20), mean age 41 years (18–65) underwent IGS implantation. Mean BMI was 41 (35–57), mean weight 115.0 kg (65–160) and mean excess weight (EW) 52 kg (13–89). The IGS was actived 30 days after implantation. In a subset of 19 patients studied further, 0, 6, and 12 months appetite and satiety score were evaluated and 0 and 6 months ghrelin profile was analyzed.

Results

The mean ± standard error %EWL was: 8.6±1.8 at 1 month, 15.8±2.3 at 3 months, 17.8±2.6 at 6 months, 21.0±3.5 at 10 months, and 21.0±5.0 at 15 months. There were no intraoperative surgical or long-term complications. 7 intra-operative gastric penetrations occurred, observed by gastroscopy, without sequelae. 1 patient required a reoperation to remove a retained lead needle. In the subset of 19 patients, appetite was reduced and post-prandial and inter-prandial satiety was increased after IGS implantation. In the 19 patients, despite weight reduction, ghrelin did not increase.

Conclusion

IGS can be implanted laparoscopically with minimal perioperative complications. Appetite is reduced and satiety is increased after the implantation. Ghrelin levels could be one of the mechanisms explaining weight loss and weight maintenance in IGS patients. If weight loss is maintained, IGS could be considered a good option for selected patients.

Key words

Obesity device implantable gastric stimulator laparoscopy weight loss ghrelin 
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Copyright information

© FD-Communications Inc. 2004

Authors and Affiliations

  • Maurizio De Luca
    • 1
  • Gianni Segato
    • 1
  • Luca Busetto
    • 1
  • Franco Favretti
    • 1
  • Franz Aigner
    • 2
  • Helmut Weiss
    • 2
  • Charles de Gheldere
    • 3
  • Giorgio Gaggiotti
    • 4
  • Jacques Himpens
    • 5
  • Jorge Limao
    • 10
  • Matthias Scheyer
    • 7
  • Mauro Toppino
    • 8
  • Ernst L. Zurmeyer
    • 9
  • Giorgio Bottani
    • 10
  • Heinrich Penthaler
    • 11
  1. 1.Department of SurgeryRegional Hospital of VicenzaVicenzaItaly
  2. 2.University Hospital Of InnsbruckAustria
  3. 3.H. Hart HospitalBelgium
  4. 4.University Hospital INRCA-IRCCSItaly
  5. 5.St.-Blasius HospitalBelgium
  6. 6.Egas Muniz HospitalPortugal
  7. 7.Krankenhaus der StadtAustria
  8. 8.Ospedale MolinetteItaly
  9. 9.Städisches KrankenhausGermany
  10. 10.Asilo VittoriaItaly
  11. 11.Ospedale di BolzanoItaly

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