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The Italian Longitudinal Study on Aging (ILSA): Design and methods

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Abstract

The Italian Longitudinal Study on Aging (ILSA) is a population-based, longitudinal study of the health status of Italians aged 65–84 years. The main objectives of ILSA are the study of the prevalence and incidence rates of common chronic conditions in the older population, and the identification of their risk and protective factors. ILSA is also designed to assess age-associated physical and mental functional changes. A random sample of 5632 individuals, stratified by age and gender using the equal allocation strategy, was identified on the demographic lists of the registry office of eight municipalities: Genova, Segrate (Milano), Selvazzano-Rubano (Padova), Impruneta (Firenze), Fermo (Ascoli Piceno), Napoli, Casamassima (Bari), and Catania. An extensive investigation, including interviews, physical exams, and laboratory tests, was conducted at baseline to identify the presence of cardiovascular disease (ischemic heart disease, hypertension, congestive heart failure, arrhythmia, intermittent claudication), diabetes, impaired glucose tolerance, thyroid dysfunction, dementia, parkinsonism, stroke, and peripheral neuropathy, as well as assess physical and mental functional status. The baseline examination was carried out between March 1992 and June 1993; a second comprehensive examination will begin in March 1995. An interim hospital discharge data survey and a mortality survey are currently ongoing to assess the hospitalization rate and the cause-specific mortality rate in this study cohort. (Aging Clin. Exp. Res. 6: 464-473, 1994)

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References

  1. Demographic Yearbook, United Nations, Statistical Office, 1991.

  2. Myers G., Maggi S.: Worldwide Population Aging: Implications for Health Research. Aging Clin. Exp. Res. 5: 77–79, 1993.

    Article  CAS  Google Scholar 

  3. Dupont W.D., Plummer W.D.: Power and sample size calculation. Controlled Clinical Trials 11: 116–128, 1990.

    Article  PubMed  CAS  Google Scholar 

  4. Folstein M.F., Folstein S.E., Mc Hugh P.R.: Mini-mental State: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12: 189–198, 1975.

    Article  PubMed  CAS  Google Scholar 

  5. De Renzi E., Faglioni P., Ruggini C.: Prove di memoria verbale di impiego clinico per la diagnosi di amnesia. Arch. Psicol. Neurol. Psichiatr. 3: 303–308, 1977.

    Google Scholar 

  6. Spinnler H., Tognoni G.: Standardizzazione e taratura italiana di test neurologici. Ita. J. Neurol. Sci. (Suppl. 8): 47-50, 1987.

  7. Brink T.L., Yesavage J.A., Lum O., Heersema P.H., Adey M., Rose T.L.: Screening tests for geriatric depression. Clinical Gerontologist 1: 37–43, 1982.

    Article  Google Scholar 

  8. Katz S., Downs T.D., Cash H.R., Grotz R.C.: Progress in development of the index of ADL. Gerontologist 1: 20–30, 1970.

    Article  Google Scholar 

  9. Lawton M.P., Brody I.A.M.B.: Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9: 179–186, 1969.

    Article  PubMed  CAS  Google Scholar 

  10. Rose G.A., Blackburn H., Gillum R.F., Prineas R.J.: Cardiovascular Survey Methods. Monograph Series No. 56. World Health Organization, Geneva, 1982.

    Google Scholar 

  11. Nevitt M.C., Cummings S.R., Kidd S., Black D.: Risk factors for recurrent nonsyncopal falls. JAMA 261: 2663–2668, 1989.

    Article  PubMed  CAS  Google Scholar 

  12. World Health Organization, ICD-9, CM: International Classification of Diseases, ed. 9 revised. WHO Publication, Geneva, 1982.

    Google Scholar 

  13. Consiglio Nazionale delle Ricerche: Progetto Finalizzato Invecchiamento, Rapporto Consuntivo 1992.

  14. Guenzel P.J., Berckmans T.R., Cannell C.F.: General Interviewing Techniques. ISR, The University of Michigan, Ann Arbor, 1983.

  15. 1988 Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Arch. Intern. Med. 148: 1023-1029, 1988.

    Google Scholar 

  16. ARIC Investigators: The Atherosclerosis Risk in Communities (ARIC) Study: Design and Objectives. Am. J. Epidemiol. 129: 687–702, 1989.

    Google Scholar 

  17. Fried L., Borhani N.O., Enright P., for the CHS Research Group: The Cardiovascular Health Study: Design and Rationale. Ann. Epidemiol. 1: 263–276, 1991.

    Article  PubMed  CAS  Google Scholar 

  18. WHO Expert Committee on Diabetes. Diabetes, 28: 1039–1057, 1979.

    Google Scholar 

  19. American Psychiatric Association: Diagnostic and Statistical Manual of mental disorders, ed. 3, revised (DSM-III-R). American Psychiatric Association, Washington DC, 1987, pp. 97–163.

    Google Scholar 

  20. McKhann G., Drachman D., Folstein M., Katzman R., Proce D., Stadlan I.A.M.B.: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34: 939–944, 1984.

    Article  PubMed  CAS  Google Scholar 

  21. World Health Organization, ICD-10: International Classification of Diseases and related health problems, ed. 10, Ch 5, Categories F00-F99. Mental behavioral and developmental disorders, clinical description and diagnostic guidelines. WHO Publication, Geneva, 1992.

    Google Scholar 

  22. Roth M., Tym E., Mountjoy C.Q., Huppert F.A., Hendrie H., Verma S., Goddard R.: CAMDEX: a standardized instrument for the diagnosis of mental disorders in the elderly with special reference to the early detection of dementia. Br. J. Psychiatry 149: 698–709, 1986.

    Article  PubMed  CAS  Google Scholar 

  23. Pfeffer R.I., Kurosaki T.T., Harrah C.H., Chance J.M., Filos S.: Measurements of functional activities in older adults in the community. Gerontology 37: 323–329, 1982.

    Article  CAS  Google Scholar 

  24. Hatano S.: Experience from a multicenter stroke register, a preliminary report. Bull. WHO 54: 541–553, 1976.

    PubMed  CAS  Google Scholar 

  25. Bamford J., Sandercock P., Dennis M., Burn J., Warlow C.: A prognostic study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project 1981–86. J. Neurol. Neurosci. Psychiatry 53: 16–22, 1990.

    Article  CAS  Google Scholar 

  26. Dyck P.J.: The causes, classification, and treatment of peripheral neuropathy. N. Engl. J. Med. 307: 283–293, 1982.

    Article  PubMed  CAS  Google Scholar 

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Participating Centres and Principal Investigators of the ILSA: Genova: C. Gandolfo, C. Loeb; Milano: N. Canal; Padova: L. Battistin, G. Enzi; Firenze: A. Ghetti, D. Inzitari, R. Vergassola; Ascoli Piceno: S. Bonaiuto; Napoli: F. Rengo; Bari: A. Capurso, P. Livrea; Catania: L. Motta.

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Maggi, S., Zucchetto, M., Grigoletto, F. et al. The Italian Longitudinal Study on Aging (ILSA): Design and methods. Aging Clin Exp Res 6, 464–473 (1994). https://doi.org/10.1007/BF03324279

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