A/H5N1 Prepandemic Influenza Vaccine (Vepacel®): A Guide to Its Use
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- Keating, G.M., Plosker, G.L. & Lyseng-Williamson, K.A. BioDrugs (2012) 26: 425. doi:10.1007/BF03261899
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Vepacel® is a prepandemic influenza vaccine (whole virion, Vero cell-derived, inactivated) containing antigen of H5N1 strain A/Vietnam/1203/2004 and is approved for use in the EU. Clinical immunogenicity studies with the vaccine have demonstrated good functional neutralizing antibody responses against the vaccine strain (A/Vietnam/1203/2004), and cross-reactivity against H5N1 strains from other clades. In general, adverse events observed in clinical immunogenicity studies with a whole virions H5N1 vaccine (A/Vietnam/1203/2004) were similar to those reported with non-adjuvanted, inactivated, split virion seasonal influenza vaccines.