Drug Investigation

, Volume 3, Issue 4, pp 220–224

Comparison of Metronidazole 1% Cream Versus Oral Tetracycline in Patients with Rosacea

Authors

  • Daniel Schachter
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Ricky Kanee Schachter
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Barry Long
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Norman Shiffman
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Robert Lester
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Stephen Miller
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Howard Bargman
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Richard Haber
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
  • Jean Bourgouin
    • Women’s College Hospital
    • General Practice in Ontario, and Rhône Poulenc Rorer Canada
Original Research Article

DOI: 10.1007/BF03259568

Cite this article as:
Schachter, D., Schachter, R.K., Long, B. et al. Drug Invest. (1991) 3: 220. doi:10.1007/BF03259568

Summary

Metronidazole 1% cream, applied twice daily, was compared with tetracycline 250mg, administered orally 3 times daily, in a 2-month double-blind multicentre study of 101 patients with rosacea.

Both metronidazole and tetracycline significantly (p < 0.05) reduced mean numbers of pustules and papules by at least 50% within 1 month of treatment. This was followed by further decreases in the mean number of papules and a levelling off in numbers of pustules at month 2 in both groups. Overall, patients in both groups considered their condition ‘much improved’ relative to that before treatment, and physicians considered their patients’ conditions improved without significant interference from adverse effects.

The results indicate that metronidazole, applied topically as a 1% cream twice daily, is as well tolerated and as effective as standard therapy with tetracycline for the treatment of rosacea.

Copyright information

© Adis International Limited 1991