Molecular Diagnosis & Therapy

, Volume 13, Issue 4, pp 209–215

Circulating Tumor Cells as Markers for Cancer Risk Assessment and Treatment Monitoring

Current Opinion

DOI: 10.1007/BF03256327

Cite this article as:
Kasimir-Bauer, S. Mol Diag Ther (2009) 13: 209. doi:10.1007/BF03256327


Carcinomas of epithelial origin represent the majority of malignancies in Europe. A substantial number of patients develop recurrent carcinoma, which is explained by tumor-cell dissemination into distant organs, preferentially bone marrow, which often occurs prior to surgery. In contrast to disseminated tumor cells in bone marrow, for which the prognostic value has been demonstrated, the role of circulating tumor cells (CTCs) in blood is not yet completely understood. Since bone marrow aspiration is less accepted by patients than blood withdrawal, it would be highly desirable to replace bone marrow aspiration by blood analysis. Presently, a variety of seemingly promising methods for the detection and characterization of CTCs are under evaluation, including immunocytologic and molecular approaches. However, these methods still need to be proven useful in clinical studies. The majority of studies published on CTCs to date have been related to primary and metastatic breast cancer; therefore, this article mainly addresses the role of CTCs in breast cancer.

Copyright information

© Adis Data Information BV 2009

Authors and Affiliations

  1. 1.Department of Gynecology and Obstetrics, University Hospital EssenUniversity of Duisburg-EssenEssenGermany
  2. 2.Klinik für Frauenheilkunde und GeburtshilfeUniversitätsklinikum EssenEssenGermany