Video-assisted thoracoscopic lobectomy reduces cytokine production more than conventional open lobectomy

  • Kazuro Sugi
  • Yoshikazu Kaneda
  • Kensuke Esato
Original Article

DOI: 10.1007/BF03218114

Cite this article as:
Sugi, K., Kaneda, Y. & Esato, K. Jpn J Thorac Caridovasc Surg (2000) 48: 161. doi:10.1007/BF03218114

Abstract

Objective: We studied cytokine changes after video-assisted thoracoscopic lobectomy and conventional lobectomy in patients with stage IA lung cancer. Methods: From June, 1997, 20 consecutive patients with stage IA non small-cell lung carcinoma underwent either conventional lobectomy via an open thoracotomy (n = 10) or video-assisted thoracoscopic lobectomy (n = 10). The cytokine concentration in serum and pleural fluid were measured for 6 days postoperatively. Results: Interleukin-6 and interleukin-8 leads peaked at 3 h or 1 day after surgery. Cytokine levels in pleural fluid were more than 100 times higher than corresponding systemic levels. The increase of interleukin-6 in pleural fluid 3 hours after surgery was significantly smaller in video-assisted thoracoscopic lobectomy (3971 ± 2793 pg/mL for video-assisted thoracoscopic lobectomy vs. 23274 ± 8426 pg/mL for open lobectomy). There were no significant differences in the serum interleukin-6 and interleukin-8 concentrations between the 2 groups. Conclusion: The thoracoscopic approach lessened the increase of cytokines in pleural fluid, but benefits of reduced cytokine production in video-assisted thoracoscopy remain to be clarified.

Key words

VATS lobectomycytokineinterleukin-6interleukin-8human

Copyright information

© The Japanese Society of Thoracic and Cadiovascular Surgery 2000

Authors and Affiliations

  • Kazuro Sugi
    • 1
  • Yoshikazu Kaneda
    • 1
    • 2
  • Kensuke Esato
    • 1
    • 2
  1. 1.Department of Clinical ResearchNational Sanyo HospitalYamaguchiJapan
  2. 2.First Department of SurgeryYamaguchi University School of MedicineUbeJapan