Abstract
To search for the anti-diabetic principle from the stem bark ofKalopanax pictus, seven kinds of chemical constituents including hederagenin glycosides and phenolic glycosides were isolated. The anti-diabetic evaluation of these isolates in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hederagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hederagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.
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Park, HJ., Kim, DH., Choi, JW. et al. A potent anti-diabetic agent fromKalopanax pictus . Arch. Pharm. Res. 21, 24–29 (1998). https://doi.org/10.1007/BF03216748
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DOI: https://doi.org/10.1007/BF03216748