Toxicology and Environmental Health Sciences

, Volume 1, Issue 1, pp 64–68

Preparation of folic acid-chitosan complex (eco-yellow) and its application for adsorption of mutagens and carcinogens

Original Paper

DOI: 10.1007/BF03216465

Cite this article as:
Jeon, H., Kim, Y. & Ryu, J. Toxicol. Environ. Health. Sci. (2009) 1: 64. doi:10.1007/BF03216465


Folic acid, a pteridine derivative, is abundant in liver and green plants and is a growth factor for some bacteria. Chitosan is a unique polysaccharide derived from chitin and is utilized as adsorbents of organic trace pollutants in environmental water sample. In this study, we have found that chitosan was suitable as a solid support to carry folic acid. And it was examined that folic acid could form an insoluble material when mixed with chitosan, a polyglucosamine, and the solid chitosan-folic acid complex (eco-yellow) thus prepared could efficiently trap polycyclic mutagenic compounds. The adsorption of the test compounds was observed using UV/Visible spectrometry. The order of extent of removal by eco-yellow was B[a]P (62.0%)>2-AA (56.2%)>QC (55.9%)>Trp-p-2 (40.2%). From these results, eco-yellow may be expected as a useful adsorber for several polycyclic mutagens and carcinogens.


Folic acid-chitosan complexAdsorptionPolycyclic mutagensCarcinogens

Copyright information

© The Korean Society of Environmental Risk Assessment and Health Science and Springer 2009

Authors and Affiliations

  1. 1.Busan Development InstituteBusanKorea
  2. 2.Cellular and Molecular Toxicology LaboratoryKorea Institute of Science and Technology (KIST)SeoulKorea