Scientific Papers

Gold Bulletin

, Volume 43, Issue 1, pp 29-41

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Gold nanoparticle-based biosensors

  • Yuanyuang LiAffiliated withKey Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
  • , Hermann J. SchluesenerAffiliated withInstitute of Brain Research, Hospital of Tuebingen University
  • , Shunqing XuAffiliated withKey Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology

Abstract

The unique properties of gold nanoparticles have stimulated the increasing interest in the application of GNPs in interfacing biological recognition events with signal transduction and in designing biosensing devices exhibiting novel functions. The optical properties of GNPs provide wide range opportunities for construction optical biosensors. The excellent biocompatibility, conductivity, catalytic properties and high surface-to-volume ratio and high density of GNPs facilitate extensive application of GNPs in construction of electrochemical and piezoelectric biosensors with enhanced analytical performance with respect to other biosensor designs. In this article, the recent advances in construction of GNP-based optical, electrochemical and piezoelectric biosensors are reviewed, and some illustrative examples given, with a focus on the roles GNPs play in the biosensing process and the mechanism of GNPs for improving the analytical performances. Finally, the review concludes with an outline of present and future research for the real-world applications.

Keywords

gold nanoparticle biosensor optical sensor electrochemical sensor piezoelectric sensor