Journal of NeuroVirology

, Volume 16, Issue 6, pp 445–456

Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus

  • Michelle M Mielke
  • Veera Venkata Ratnam Bandaru
  • Justin C McArthur
  • Michael Chu
  • Norman J Haughey
Article

DOI: 10.1007/BF03210850

Cite this article as:
Mielke, M.M., Bandaru, V.V.R., McArthur, J.C. et al. Journal of NeuroVirology (2010) 16: 445. doi:10.1007/BF03210850

Abstract

Despite widespread use of antiretroviral therapies to control replication of the human immunodeficiency virus (HIV), dysfunctions of cognition that are collectively termed HIV-associated neurocognitive disorders (HAND) still occur in approximately 50% of those infected by the virus. Currently there is not a biomarker that can identify HIV-infected people who are at risk for the development of HAND. Previous studies have identified particular sphingolipid species that are dysregulated in HAND, but the neurocognitive correlates of these biochemical findings are not currently understood. To address this question, we compared cerebrospinal fluid (CSF) levels of sphingomyelin, ceramide, and sterol species with performance on standard neurological tests designed to assess the function of multiple cognitive and motor domains in HIV-infected subjects. We found that sphingomyelin:ceramide ratios for acyl chain lengths of C16∶0, C18∶0, C22∶0, and C24∶0 were associated with worse performance on several indices of memory. The most striking finding was for the acyl chain of C18∶0 that consistently associatedwith performance onmultiple tests of memory. These findings suggest that the sphingomyelin:ceramide ratio for C18∶0 may be a reasonable surrogate marker for memory dysfunction in HIV-infected subjects.

Keywords

ceramide CSF HAND HIV mass spectrometry memory neuron RAVLT sphingolipids sphingomyelin 

Copyright information

© Journal of NeuroVirology 2010

Authors and Affiliations

  • Michelle M Mielke
    • 1
  • Veera Venkata Ratnam Bandaru
    • 2
  • Justin C McArthur
    • 2
  • Michael Chu
    • 2
  • Norman J Haughey
    • 2
  1. 1.Department of Psychiatry Richard T. Johnson Division of Neuroimmunology and Neurological InfectionsThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological InfectionsThe Johns Hopkins University School of MedicineBaltimoreUSA

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