Journal of Applied Genetics

, Volume 51, Issue 1, pp 87–94

Association between a-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis

Original Article

DOI: 10.1007/BF03195715

Cite this article as:
Wang, R., Zhong, B., Liu, Y. et al. J Appl Genet (2010) 51: 87. doi:10.1007/BF03195715


Linkage and association studies suggested the relationship between a-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and α-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96, 2.04),P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI):1.33 (1.06, 1.69),P = 0.02] but not in Caucasian people [OR (95%CI):1.98 (0.57, 6.92),P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of a-adducin Gly460Trp polymorphism in salt-sensitive hypertension.


α-adducin meta-analysis polymorphism salt-sensitive hypertension 

Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2010

Authors and Affiliations

  1. 1.Department of CardiologyAffiliated Hospital of Youjiang Medical College for NationalitiesBaise, GuangxiChina
  2. 2.Affiliated Mental Health Center, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan, HubeiChina
  3. 3.Tianjin University of TCMTianjinChina
  4. 4.Baylor College of Medicine and The University of Texas MD Anderson Cancer CenterHouston, TexasUSA