European Journal of Drug Metabolism and Pharmacokinetics

, Volume 9, Issue 3, pp 267–274

Pharmacokinetics of oxiracetam following intravenous and oral administration in healthy volunteers

  • E. Perucca
  • A. Albrici
  • G. Gatti
  • R. Spalluto
  • M. Visconti
  • A. Crema
Original Papers

DOI: 10.1007/BF03189650

Cite this article as:
Perucca, E., Albrici, A., Gatti, G. et al. European Journal of Drug Metabolism and Pharmacokinetics (1984) 9: 267. doi:10.1007/BF03189650

Summary

The kinetics of oxiracetam after single intravenous and oral doses (2000 mg) were investigated in four healthy volunteers. Following intravenous administration, the decline in serum levels showed a prolonged, rapid phase followed by a delayed terminal phase. Mean residence times ranged from 3.9 to 6.5 h. Volumes of distribution ranged from 0.9 to 1.81 · kg−1, whereas clearance values ranged from 100 to 119 ml·.h−1· kg -1 More than 90% of the intravenous dose was recovered unchanged in the urine within 48 h. Oral administration resulted in peak levels within 1–2 h; thereafter, the decline in serum levels showed a pattern similar to that observed after the intravenous dose — almost 50% of the oral dose was excreted in the urine within 6 h. The absolute availability of oral oxiracetam was 75 ± 7%.

Key-words

Pharmacokineticsoxiracetambioavailability

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • E. Perucca
    • 1
  • A. Albrici
    • 2
  • G. Gatti
    • 1
  • R. Spalluto
    • 2
  • M. Visconti
    • 2
  • A. Crema
    • 1
  1. 1.Institute of Medical PharmacologyUniversity of PaviaPaviaItaly
  2. 2.ISF Laboratories for Biomedical ResearchTrezzano S/NMilanItaly