Summary
In this study the authors compared the pharmacokinetics of three zinc salts after parenteral and oral administration to rabbits: zinc sulfate, a soluble mineral salt; zinc pantothenate, a soluble organic salt; and zinc orotate, an insoluble organic salt. The results obtained with the two soluble salts were not significantly different (p<0.05). Therefore they appear to be bioequivalent. The plasma concentration curve for zinc orotate shows a faster distribution (α) and elimination phase (α) after parenteral administration, and a slower absorption phase (Ka) after oral administration, when compared with that of the other two salts. It was shown that the dissolution behaviour of these zinc salts in water does not correlate with the parameters foundin vivo.
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Amblard P., Reymond J.L., Guignier M., Guillaud J.Y. (1977). Acrodermatitis par carence en zinc au cours d’une hyperalimentation parenterale. Nouv. Presse Méd.6, (12): 1051.
Barnes P.M., Moynahan E.J. (1973). Zinc deficiency in acrodermatitis enteropathica: multiple dietary intolerance treated with synthetic diet. Proc. Roy. Soc. Med.66: 327–329.
Braun-Falco O., Von Liebe V. (1977). Zinktherapie der acrodermatits enteropathica. Münch. Med. Wschr.119, (2): 37–42.
Michaelsson G. (1974). Zinktherapie in Acrodermatitis enteropathica. Acta. Derm. Venereol.54: 377–381.
Moynahan E.J. (1975). Acrodermatitis enteropathica: une maladie génétique humaine de carence du zinc. Ann. Derm. Syph.102: 47–84.
Solomons N.W., Layden T.J., Rosenberg I.A. (1976). Plasma trace metals during total parenteral alimentation. Gastroenterology 6: 1022–1025.
Hillstrom L., Pettersson L., Hellbe L., Kjellin A., Leczinsky CG., Nordwall C. (1977). Comparison of oral treatment with zinc sulfate and placebo in acne vulgaris. Brit. J. Dermatol.97: 681–684.
Michaelsson G., Juhlin L., Vahlquist A. (1977). Effect of oral Zinc and Vitamin A in acne. Arch. Dermatol.113: 31–36.
Fiedler L., Hecht E. und W., Waldmann D., Kruse-Jarres J.D. Tierexperimentelle Untersuchungen zur Zink Absorption In: Kruse-Jarres J.D. (1979). Zinkstoffwechsel: Bedeutung für Klinik und Praxis, p. 123–127 Internationales Symposium 27 und 28 Oktober 1978 Freiburg Breisgau TM Verlag, Bad Oeynhausen.
Schwarz F.J., Kirchgessner M. Zink-Versorgunsstratus und Zink Absorption In: Kruse-Jarres J.D. (1979). Zinkstoffwechsel: Bedeutung für klinik und Praxis, p. 129–137. Internationales Symposium 27 und 28 Oktober 1978 Freiburg Breisgau TM Verlag, Bad Oeynhausen.
Guillard O., Saux M.C., Hazane C., Dumas C., Courtois Ph. (1978). Pharmacocinétique comparée du sulfate et du pantothenate de zinc. Ann. Pharmac. Fr.36: 669–676.
Lerebours E., Galmiche J.P. (1978). Le zinc en pathologie digestive. La nouv. Presse méd.37 (7): 3351–3355.
Parker M., Humoller F., Mahler D. (1967). Determination of copper and zinc in Biological Material Clin. Chem. 13: 40–48.
Sprague S., Slavin W. (1965). Determination of ion, copper and zinc in blood serum by an atomic absorption method requiring only dilution. At. Absorp. News.,4: 228–233.
Hinkel G.K., Le Petit, G. (1973). Pädiatrie,12, 63 cité par: Köhler E., Meyer F.P., Walther H., (1977). Zur Pharmakokinetik von Methylglukaminorotat. Zbl. Phar.,116 (4): 399–402.
Lifschitz M.D., Kenkin R.I., (1971). Orcadian variation in copper and zinc in man. J. Appl. Physiol.31: 88–92.
Evans G.W. (1976). Zinc absorption and transport, In: Prasad, A.S. ed., Trace elements in human health and disease. Vol. I, Acad. Press, New-York pp. 181–187.
Andersson K.E., Bratt L., Dencker H., Kamme C., Lanner E. (1976). Inhibition of tetracycline absorption by zinc. Europ. J. Clin. Pharmacol.10 59–62.
Halsted J.A., Hackley B.M., Smith J.C. Jr (1968). Plasma-zinc and copper in pregnancy and after oral contraceptives. Lancet2: 287–279.
Henkin RJ. (1976). Trace metals in endocrinology. Med. Clin. North Am.,60: 119–191.
Reinhold J.G., Faradji B., Abadj P., Ismail Beigi F., (1976). Trace elements in human health and disease. Vol. 1: Zinc and copper Acad. Press, New-York, pp. 163–180.
Mikac-Devic D. (1970). Methodology of zinc determination and the role of zinc in biochemical processes. Adv. Clin. Chem.,13: 271–333.
Giroux E., Prakash N.J., (1977). Influence of zinc ligand mixtures on serum zinc levels in rats. J. Pharm. Sci.,66, 3: 391–395.
Freemann R.M., Taylor P.R., (1977). Influence of histidine administration on zinc metabolism in the rat. Am. J. Clin. Nutr.,30: 523–527.
Briggs M.H., Briggs M., Austin J., (1971). Effects of steroid pharmaceuticals on plasma zinc. Nature,232: 480–481.
Michaelsson G., Juhlin L., Wahlquist A., (1977). Effects of oral zinc and vitamin A in acne. Arch. Dermatol.,113: 31–36.
Wang J., Pierson R.N., (1975). Distribution of zinc in skeletal muscle and liver tissue in normal and dietary controlled alcoholic rats. J. Lab. Clin. Med.,85: 50–58.
Reinhold J.G., Lahimgarzadeh A., Nasr K., Nedayati H., (1973). Effects of purified phytate and phytate rich bread upon metabolism of zinc, calcium, phosphorus and nitrogen in man. Lancet,1: 283–288.
Richards M.P., Cousins RJ. (1977). Isolation of an intestinal metallothioneine induced by parenteral zinc. Biochem. Biophys. Res. Commun.,75 (2): 286–294.
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Andermann, G., Dietz, M. The bioavailability and pharmacokinetics of three zinc salts: Zinc pantothenate, zinc sulfate and zinc orotate. European Journal of Drug Metabolism and Pharmacokinetics 7, 233–239 (1982). https://doi.org/10.1007/BF03189570
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DOI: https://doi.org/10.1007/BF03189570