International Journal of Hematology

, Volume 76, Supplement 1, pp 226–247

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?

  • Richard K. Burt
  • Shimon Slavin
  • William H. Burns
  • Alberto M. Marmont
Stem Cell Transplantation in Autoimmune Disease

DOI: 10.1007/BF03165251

Cite this article as:
Burt, R.K., Slavin, S., Burns, W.H. et al. Int J Hematol (2002) 76(Suppl 1): 226. doi:10.1007/BF03165251

Abstract

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to B and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models, adoptive transfer of HSCs, depending on circumstances, may cause, prevent, or cure autoimmune diseases. Clinical trials have reported early remission of otherwise refractory autoimmune disorders after either autologous or allogeneic hematopoietic stem cell transplantation (HSCT). By percentage of transplantations performed, autoimmune diseases are the most rapidly expanding indication for stem cell transplantation. Although numerous editorials or commentaries have been previously published, no prior review has focused on the immunology of transplantation tolerance or development of phase 3 autoimmune HSCT trials. Results from current trials suggest that mobilization of HSCs, conditioning regimen, eligibility and exclusion criteria, toxicity, outcome, source of stem cells and posttransplantation follow-up need to be disase specific. HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies. *** DIRECT SUPPORT *** A00RC002 00010

Copyright information

© The Japanese Society of Hematology 2002

Authors and Affiliations

  • Richard K. Burt
    • 1
  • Shimon Slavin
    • 2
  • William H. Burns
    • 3
  • Alberto M. Marmont
    • 4
  1. 1.Division of Immune Therapy and Autoimmune DiseaseNorthwestern University Medical CenterChicago
  2. 2.Department of Bone Marrow Transplantation & Cancer ImmunotherapyHadassah University HospitalJerusalemIsrael
  3. 3.Bone Marrow TransplantationMedical College of WisconsinMilwaukee
  4. 4.Divisione di Ematologia II, Centro Trapianti di Midollo OsseoAzienda Ospedaliera S. MartinoGenoaItaly

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