International Journal of Hematology

, Volume 76, Supplement 2, pp 271–277

Non-myeloablative hematopoietic cell transplant for treatment of nonmalignant disorders in children

Authors

  • Ann E. Woolfrey
    • Fred Hutchinson Cancer Research Center and University of Washington
  • Michael A. Pulsipher
    • Pediatric Blood and Marrow transplant Clinic
  • Rainer Storb
    • Fred Hutchinson Cancer Research Center and University of Washington
Non-malignant Hematologic Disorders in Childhood

DOI: 10.1007/BF03165129

Cite this article as:
Woolfrey, A.E., Pulsipher, M.A. & Storb, R. Int J Hematol (2002) 76: 271. doi:10.1007/BF03165129

Abstract

Hematopoietic stem cell transplantation (HCT) may offer the only curative therapy for certain life-threatening immune deficiency disorders. Conventional HCT poses a risk to patients for severe morbidity, mortality, and late sequelae resulting from myeloablative preparative regimens. This review summarizes the development of nonmyeloablative regimens that have the potential to reduce both short- and long-term risks of HCT. Results of NM-HCT in a small number of patients indicate that this procedure may play an important role in treatment of life-threatening immune deficiencies.

Copyright information

© The Japanese Society of Hematology 2002