Annals of Nuclear Medicine

, Volume 13, Issue 3, pp 161–167

Comparison of three PET dopamine D2-like receptor ligands, [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone, in rats

Authors

    • Positron Medical CenterTokyo Metropolitan Institute of Gerontology
  • Nobutaka Hayakawa
    • Positron Medical CenterTokyo Metropolitan Institute of Gerontology
    • Showa College of Pharmaceutical Sciences
  • Nobuo Ogi
    • Positron Medical CenterTokyo Metropolitan Institute of Gerontology
    • Showa College of Pharmaceutical Sciences
  • Keiichi Oda
    • Positron Medical CenterTokyo Metropolitan Institute of Gerontology
  • Hinako Toyama
    • Positron Medical CenterTokyo Metropolitan Institute of Gerontology
  • Kazutoyo Endo
    • Showa College of Pharmaceutical Sciences
  • Akira Tanaka
    • Showa College of Pharmaceutical Sciences
  • Michio Senda
    • Positron Medical CenterTokyo Metropolitan Institute of Gerontology
Original Article

DOI: 10.1007/BF03164856

Cite this article as:
Ishiwata, K., Hayakawa, N., Ogi, N. et al. Ann Nucl Med (1999) 13: 161. doi:10.1007/BF03164856

Abstract

We studied the tracer kinetics of three dopamine D2-like receptor ligands, [11C]raclopride ([11C]RAC), [11C]nemonapride ([11C]NEM) and [11C]N-methylspiperone ([11C]MSP), in anesthetized rats by tissue dissection,ex vivo ARG and PET in order to clarify their characteristics for PET imaging. Thein vivo affinity of the three ligands for the striatum ([11C]MSP > [11C]NEM > [11C]RAC) obeyed thein vitro affinity for dopamine D2 receptors. The affinity of [11C]RAC and [11C]MSP for the cerebellum was very low, but the affinity of [11C]NEM for the cerebellum was compatible to that for the cortex and was not to be ignored. Also the affinity of [11C]MSP for the cortex was relatively high. [11C]RAC showed the highest selectivity. The striatal PET image with [11C]RAC was clearer than that with [11C]NEM or [11C]MSP, but the activity decreased much faster than that measured by tissue dissection because of the partial volume effect. The striatal activity with [11C]NEM remained high and that with [11C]MSP gradually increased. [11C]RAC and [11C]MSP, but not [11C]NEM, showed a high accumulation in the periorbital region.

Key words

raclopridenemonaprideN-methylspiperonedopamine D2-like receptorratPET

Copyright information

© Springer-Verlag 1999