Annals of Nuclear Medicine

, Volume 11, Issue 3, pp 233–241

Noninvasive identification of left ventricular involvements in arrhythmogenic right ventricular dysplasia: Comparison of123I-MIBG,201TlCl, magnetic resonance imaging and ultrafast computed tomography

  • Nobukazu Takahashi
  • Yoshio Ishida
  • Masakazu Maeno
  • Yoshiaki Hirose
  • Shigeo Kawano
  • Shyuji Fukuoka
  • Kohei Hayashida
  • Sachio Kurbayashi
  • Seiki Hamada
  • Naoaki Yamada
  • Makoto Takamiya
  • Katuro Shimomura
  • Tohru Ohe
Original Article

DOI: 10.1007/BF03164769

Cite this article as:
Takahashi, N., Ishida, Y., Maeno, M. et al. Ann Nucl Med (1997) 11: 233. doi:10.1007/BF03164769

Abstract

We examined the feasibility of myocardial123I-MIBG,201TlCl, magnetic resonance imaging (MRI) and ultrafast computed tomography (UFCT) for the early detection of left ventricular involvements in 15 patients with arrhythmogenic right ventricular dysplasia (ARVD). Radionuclide ventriculography (RNV) and myocardial imaging with123I-MIBG,201TlCl, MRI and UFCT were performed in all 15 patients and in 10 normal subjects.

The patients’ scans were visually interpreted by two nuclear medicine physicians taking into consideration the extent score (ES) and severity score (SS) calculated by using the bull’s-eye view in relation to normal data derived from the normal subjects. The left ventricular ejection fraction (LVEF) was measured by RNV. Fourteen (93%) patients showed regional123I-MIBG defects, while 12 (80%) patients showed regional201TlCl defects. The ES and SS were higher in123I-MIBG than201TlCl (ES: 31.5± 18.5 vs. 17.5+18.2, p < 0.01, SS: 34.8±42.2 vs. 16.9±37.5, p< 0.01). Abnormal UFCT and MRI findings suggesting fatty involvements of the LV myocardium were demonstrated in 7 patients (Group B), while 7 patients showed regional123I-MIBG defects without abnormal UFCT and MRI findings (Group A).123I-MIBG was significantly more sensitive than UFCT and MRI (p< 0.05), although one patient, an exception, showed abnormal UFCT findings for the apex of the LV myocardium without abnormal123I-MIBG and MRI findings. The LVEF, as a measure of LV systolic function, was better preserved in Group A than in Group B (59.3±3.6 vs. 45.8±5.8, p< 0.01).

The present findings indicated that myocardial imaging with123I-MIBG sensitively detects myocardial damage in patients with ARVD in the early stage when cardiac systolic function is still preserved.

Key words

arrhythmogenic right ventricular dysplasia123I-MIBG201TlClmagnetic resonance imagingultrafast computed tomography imaging

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Nobukazu Takahashi
    • 1
  • Yoshio Ishida
    • 1
  • Masakazu Maeno
    • 1
  • Yoshiaki Hirose
    • 1
  • Shigeo Kawano
    • 1
  • Shyuji Fukuoka
    • 1
  • Kohei Hayashida
    • 1
  • Sachio Kurbayashi
    • 1
  • Seiki Hamada
    • 1
  • Naoaki Yamada
    • 1
  • Makoto Takamiya
    • 1
  • Katuro Shimomura
    • 2
  • Tohru Ohe
    • 3
  1. 1.Department of RadiologyNational Cardiovascular CenterOsakaJapan
  2. 2.Department of CardiologyNational Cardiovascular CenterJapan
  3. 3.Department of Cardiovascular MedicineOkayama University Medical SchoolJapan