A fatal case of venlafaxine overdose
- Cite this article as:
- Bosse, G.M., Spiller, H.A. & Collins, A.M. J. Med. Toxicol. (2008) 4: 18. doi:10.1007/BF03160945
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Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects.
A 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed significant QRS and QTC interval prolongation prior to his demise.
A literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.