Molecular and Chemical Neuropathology

, Volume 19, Issue 1, pp 137–145

Pro-opiomelanocortin neuropeptide receptors on developing and dystrophic muscle fibers

  • Margaret E. Smith
  • Sharon Hughes

DOI: 10.1007/BF03160174

Cite this article as:
Smith, M.E. & Hughes, S. Molecular and Chemical Neuropathology (1993) 19: 137. doi:10.1007/BF03160174


Autoradiography was used to investigate the presence of corticotropin and β-endorphin receptors on soleus, extensor digitorum longus, and diaphragm muscles of normal and dystrophic adult mice and developing mice. In both adult and developing mice, specific binding sites for both [125I]ACTH and [125I]β-endorphin were present in some fibers in all of the muscles examined. The specific binding sites appeared to be distributed over the length of the surface membrane in the fibers that expressed them. There were significantly higher proportions of fibers exhibiting the specific β-endorphin and the specific ACTH binding sites in the three muscle types in mice of 5 d of age compared to the muscles of the normal adult. There was also a higher proportion of fibers with the putative ACTH and β-endorphin receptors in the three muscle types in dystrophic mice.

Index Entries

Pro-opiomelanocortin peptidesskeletal muscledeveloping musclesdystrophic musclesβ-endorphincorticotropinsopioid receptorscorticotropin receptors

Copyright information

© Humana Press Inc. 1993

Authors and Affiliations

  • Margaret E. Smith
    • 1
  • Sharon Hughes
    • 1
  1. 1.Department of Physiology, Medical SchoolUniversity of BirminghamBirminghamUK