Molecular and Chemical Neuropathology

, Volume 17, Issue 1, pp 79–89

Aluminum-induced acute cholinergic neurotoxicity in rat

Authors

  • Jeng-Hsiung F. Peng
    • Department of Pathology, School of MedicineUniversity of Missouri-Kansas City
  • Zhi-Chung Xu
    • School of Pharmacy
  • Zhi-Xin Xu
    • School of Pharmacy
  • Joseph C. Parker
    • Department of Pathology, School of MedicineUniversity of Missouri-Kansas City
  • Edward R. Friedlander
    • Department of Pathology, School of MedicineUniversity of Missouri-Kansas City
  • Jian-Ping Tang
    • School of Pharmacy
  • Srikumaran Melethil
    • School of Pharmacy
Original Articles

DOI: 10.1007/BF03159983

Cite this article as:
Peng, J.F., Xu, Z., Xu, Z. et al. Molecular and Chemical Neuropathology (1992) 17: 79. doi:10.1007/BF03159983

Abstract

In the present study the acute effect of intravenous aluminum chloride (1 mg/kg) on choline acetyltransferase (ChAT) and acetyl-cholinesterase (AChE) activities of rats was investigated. Aluminum was found to cross the blood-brain barrier (BBB) as indicated by the detection of aluminum in the cerebrospinal fluid (CSF) 30 min after femoral vein injection. Two hours following aluminum injection, ChAT activity in the basal forebrain and hippocampus was significantly reduced by 30% and 22%, respectively, whereas no change was observed in the caudate nuclei. On the other hand, AChE activity was significantly increased by 45% in the caudate nuclei, whereas little change was observed in other brain areas. This report demonstrates that rapid transport of Al across the BBB, and the acute nature of Al neurotoxicity in rats.

Index Entries

Aluminum transportblood-brain barriercerebrospinal fluid aluminumacute aluminum effectcholinergic neurotoxicityneurofibrillary degenerationcholine acetyltransferaseacetylcholinesterase

Copyright information

© Humana Press 1992