Molecular basis of joint development
- Cite this article as:
- Dell’ Accio, F., De Bari, C. & Luyten, F.P. Japanese Journal of Rheumatology (1999) 9: 17. doi:10.1007/BF03041256
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The introduction of the techniques of molecular biology has provided powerful tools in modern biomedical research including the field of developmental biology and new insights in the molecular pathways governing joint development. The critical signals involved in the joint formation process are also likely to be involved in the maintenance and repair of the joint structures following traumatic/degenerative or inflammatory injuries. Yet, the available data on the complex set of molecular players participating in joint specification and morphogenesis are often disconnected and sometimes controversial. In this review we try to depict a comprehensive state of the art in the field and to indicate connections that may link the different molecular pathways. The elucidation of these development cascades identifies new therapeutic targets and opportunities to enhance and control repair processes in joint disorders.